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http://dx.doi.org/10.1016/S0029-7844(99)00279-3

has been cited by the following article:

• TITLE: Potential of Terpenoid Bioactive Compound Isolated from Papua Ant Nest as an Alternative Ovarian Cancer Treatment

  AUTHORS: Hasanuddin, K. Sofie Rifayani, G. Supriadi, Dikdik Kurnia, D. Adhita

  KEYWORDS: Terpenoid, Ovarian Cell Lines, Apoptotic Index

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.5 No.7, July 21, 2015

  ABSTRACT: Objectives: The purpose of this study was to determine anticancer activity of terpenoid bioactive compound isolated from Papua ant nest on ovarian cancer cells in vitro. Methods: This was a laboratory experimental study which aims to determine the potential of the terpenoid bioactive compound isolated from Papua ant nest to inhibit the growth and induce apoptotic process on ovarian cancer cells (SKO-3) in vitro. Result: Terpenoid had capability to inhibit the growth of ovarian cancer cell line (SKO-3) in vitro, with IC50 of 481 ug/ml at 48 hours and 463 ug/ml at 48 hours, respectively. At a concentration of 600 ug/ml, terpenoid was able to induce apoptotic process on ovarian cancer cell lines in vitro with the apoptotic index of 30% at 24 hours, 35% at 48 hours and 37% at 72 hours, respectively. Conclusion: Terpenoid bioactive compound isolated from Papua ant nest had the ability to inhibit the growth and was able to induce apoptotic process on ovarian cancer cell lines (SKO-3) in vitro.