TITLE:
Mast Cell Infiltration and Leukotriene Receptor Expression in Various Tumors: Possible Clinical Application of Common Pathological Findings Concerned with Tumor Development
AUTHORS:
Masao Sugamata, Tomomi Ihara, Miho Sugamata
KEYWORDS:
Mast Cell, Leukotriene Receptor, Anti-Leikotriene Therapy, Apoptosis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.7,
July
21,
2015
ABSTRACT: Since
the mechanisms of the developmental processes of tumors remain unclear, early
detection and early treatment of the tumors is necessary to save patients with
malignant tumors. Therapies currently available to patients are surgery, chemotherapy,
and radiotherapy. However, there are many patients who cannot be saved by such
therapies. In this study, we found the common features of various tumor
tissues, and we demonstrated the effect of therapeutics that target them by
using experimental rats with spontaneous tumors. 26 kinds of human tumors
(epithelial or mesenchymal origin, and malignant or benign) and Sprague-Dawley
rats with spontaneous mammary gland tumors were examined by light and electron
microscope. To detect of mast cells and leukotriene receptor, toluidine blue
stain and immunohistochemical stain were performed. The rats were orally
administered one of leukotriene receptor antagonists. We found that the
presence of numerous mast cells and expression of leukotriene receptors in
various tumor (human tumors and rat spontaneous tumors). And the therapeutic
effects, which suppressed not only tumor progress but also angiogenesis and
nerve formation, for rat tumors by administration of leukotriene receptor
antagonist could obtain. Our data suggest the possibility that allergic
reactions, in which leukotriene and leukotriene receptors in particular appear
to play an important role, are involved in the development and progression of
tumors and that it may be possible to control tumor progression by regulating
such reactions. Our results might be useful for clinical applications of
oncotherapy.