TITLE:
Serum Resistin Level and Polymorphonuclear Leukocytes Dysfunctions in Children on Regular Hemodialysis
AUTHORS:
Maha Yousef Zein, Manal Abdel-Salam, Iman Abdel-Aziz, Naglaa Fathy Mohamed
KEYWORDS:
Chronic Kidney Disease, Resistin, Dialysis, Polymorphonuclear Leukocytes
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.6 No.6,
June
26,
2015
ABSTRACT: Resistin is a secretory adipocytoine, which is expressed mainly in humans by inflammatory cells especially macrophages. Resistin serum levels are elevated in end-stage renal diseases of people having an increased risk of infections as a result of impaired polymorphonuclear leukocytes (PMNLs) functions. Objectives: To evaluate neutrophil functions (phagocytosis and oxidative burst) in children with end-stage renal disease (ESRD) on regular hemodialysis and to shed light on the contribution of resistin on neutrophil functions. Patients and Methods: The study included 40 children with ESRD on regular hemodialysis. Their ages ranged from 6 to 12 years, and they were selected from children attending the pediatric hemodialysis unit of AL-Zahraa Hospital, Al-Azher University during the period from October 2012 to December 2013. Another group of 40 apparently healthy children with matched age and sex with the patient group served as a control. Serum resistin, phagocytic index and nitro blue tetrazolium test (NBT%) were assessed in both groups. Results: There was a statistically more significant increase in resistin serum levels in cases than in controls; it was (3.25 ± 0.86 ng/ml) and (0.25 ± 0.16 ng/ml) respectively (P