TITLE:
It’s Possible to Predict a Decreased Bactericidal Effect of Biocides, through Antibiotic Resistance in ICU: Study Using a Large Sample of Bacteria and Multivariate Analysis
AUTHORS:
Irene Herruzo, Rafael Herruzo, Maria Jose Vizcaino
KEYWORDS:
Predicted, Bactericidal-Effect, Disinfectants/Antiseptics, Antibiotic-Resistance
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.5 No.2,
June
19,
2015
ABSTRACT: Objective: To determine
whether there was any association between resistance to antibiotics and
decreased susceptibility to antiseptics and disinfectants and their importance
in clinical practice. Methods: We studied a large number of microorganisms
isolated from ICU patients (high percentage of cases of antibiotic resistance).
The antibiogram (Kirby-Bauer) was determined and, in parallel, the bactericidal
effect was assessed by two methods, according to the product used: 1) Effect on
rough material (endodontic files) in 10 min, using five disinfectants; 2)
Effect on a skin equivalent (sterile cotton cloth) in 30 sec, for two alcohol
solutions. A predictive equation of the bactericidal effects versus
microorganisms’ antibiogram was obtained by multivariate methods. Results:Bactericidal efficacy was very similar
for all the products with the exception of 1% povidone-iodine. Within each
product there were no significant differences between the three groups of
microorganisms: “Enterobacteria”, “Non Fermentative Gram Negative Bacteria” and
“cocci”. Multivariate study only obtained one significant equation: 1%
chlorhexidine resistance was directly correlated with aztreonam resistance (OR
= 2.16), while resistance to imipenem and to phosphomycin acted as protection
factors (OR