TITLE:
Modifications of L-Glutamine and L-Leucine Transport in Proliferating Lymphocytes
AUTHORS:
Francisco Sanchez, Jose Luis Gil, Macarena Perán
KEYWORDS:
Cell Membrane Transport, Lymphocytes, L-Glutamine, L-Leucine, Malignancy Biomarkers
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.3,
March
31,
2015
ABSTRACT:
Lymphocytes respond to mitogens that stimulate
proliferation by increasing theirs metabolic activity. In this study we
investigate L-Glutamine and L-Leucine uptake as markers of cell response to
Concavalina A (ConcaA) stimulation, using a high-resolution flow technique. We
found that lymphocytes induced to blast transformation enhanced rate and
efficiency of amino acid uptake during cell proliferation. Considering that
increases in transport is the first quantifiable response of cells during
malignant transformation, amino acid uptake could also be useful as an early
marker of malignancy.