TITLE:
A Novel One-Pot and Efficient Procedure for Synthesis of New Fused Uracil Derivatives for DNA Binding
AUTHORS:
Bothaina A. Mousa, Ashraf H. Bayoumi, Makarem M. Korraa, Mohamed G. Assy, Samar A. El-Kalyoubi
KEYWORDS:
6-Chloro-1-methyluracil, Pyrazolo[3, 4-d]pyrimidines, 6-Aminouracils, Xanthine, Indenopyrrolopyrimidine and Indenopteridine
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.5 No.1,
March
27,
2015
ABSTRACT: Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the respective hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives. Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin respectively. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA.