Bar-Joseph, Z., Siegfried, Z., Brandeis, Z.B., Brors, B., Lu, Y., Eils, R., Dynlacht, B.D. and Simon, I. (2008) Genome-Wide Transcriptional Analysis of the Human Cell Cycle Identifies Genes Differentially Regulated in Normal and Cancer Cells. Proceedings of the National Academy of Sciences of the United States of America, 105, 955-960. http://dx.doi.org/10.1073/pnas.0704723105

has been cited by the following article:

• TITLE: Cancers in Children Ages 8 to 12 Are Injury-Related

  AUTHORS: Kirsten H. Walen

  KEYWORDS: Endomitosis, Endotetraploidization, Diplochromosomes, Reductive Division, Genomic Change, Proliferative Advantage, Wound Healing

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.2, February 9, 2015

  ABSTRACT: Cancers in young children in early growing age was a short PBS (KQED) report (11/21/2014), but without informational source, which prompted a Google search. Sports-associated injuries with medical healing treatments concluded that there were no association between these body traumas and cancer development. But there are other activities from young children, such as “dare-devil” skateboard and bicycling meter-high jumping with potential high energy falls, to serious broken-bone injuries. Falls of children are among the most common causes of US emergency response. The question is why bodily injury is associated with cancer-development? An answer to this question was exemplified by osteosarcoma in young children, which suggested that injury to growing points of bone and surrounding soft tissue cells would elicit a repair process (wound healing process) producing polyploidy with diplochromosomes. The non-mitotic reductive division of such 4-chromatid chromosomes has been shownin vitroto produce pathological cancer-like phenotypes, including gain of a proliferative advantage.