TITLE:
F0 Prenatal/Lactation Diets Varying in Saturated Fat and Long-Chain Polyunsaturated Fatty Acids Alters the Insulin Sensitivity of F1 Rats Fed a High Fat Western Diet Post-weaning
AUTHORS:
Daniel C. Benyshek, Julie J. Kachinski, Hongbin Jin
KEYWORDS:
Developmental Origins, LC-PUFAs, Insulin Resistance, Animal Modelling
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.4 No.12,
December
25,
2014
ABSTRACT: Previous research has shown
that prenatal diets rich in specific nutrients (e.g. taurine, omega-3 fatty
acids) may provide protective cardiometabolic effects for adult offspring. The
purpose of the current study was to investigate the potential of a
prenatal-lactation diet rich in omega-3 long-chain polyunsaturated fatty acids
(omega-3 LC PUFAs) to improve metabolic function in offspring fed a high
saturated fat “Western” diet postweaning. We compared growth and metabolic biomarkers
of three groups of Sprague Dawley rat offspring all weaned to a high saturated fat
“Western” (Western) diet, but whose mothers were fed one of three different
diets during pregnancy-lactation: 1) omega-3 “PUFA”-rich (PUFA/Western); 2)
control (Control/Western); and 3) high saturated fat “Western”
(Western/Western). PUFA/Western offspring had significantly lower fasting
insulin (P Western
animals. Additionally, mean HOMA-IR, fasting plasma insulin, and triglycerides
were 19%, 10% and 14% lower, respectively, than those of Control/Western
animals, although these differences were not statistically significant.
Western/Western adult offspring had the highest fasting plasma insulin,
triglycerides, and insulin-resistance (HOMA-IR) of the three groups. Our
results indicated that a maternal omega-3 PUFA-rich diet during
pregnancy-lactation may provide modest protective metabolic effects for adult
offspring, even when consuming a high energy and saturated fat diet.