TITLE:
Effects of Nickel Chloride on Histopathological Lesions and Oxidative Damage in the Thymus
AUTHORS:
Kun Tang, Jian Li, Shuang Yin, Hongrui Guo, Jie Deng, Hengmin Cui
KEYWORDS:
Nickel Chloride, Histopathological Lesions, Oxidative Damage, Thymus, Broiler
JOURNAL NAME:
Health,
Vol.6 No.21,
December
23,
2014
ABSTRACT: The purpose of this
study was to observe the histopathological
lesions and oxidative damage induced by dietary nickel chloride (NiCl2)
in the thymus. A total of 280 one-day-old
avian broilers were divided into four groups and fed on a corn-soybean basal
diet as the control diet or the same basal diet supplemented with 300, 600, and
900 mg/kg of NiCl2 for 42 days. In the NiCl2-treated
groups, the broiler weight and thymic relative weight were
significantly (P P P P 2-treated groups than those in the control
group, while MDA content was higher. The above-mentioned
results demonstrated that dietary NiCl2 in excess of 300
mg/kg could reduce the broiler weight and thymic relative weight, and cause
histopathological lesions and oxidative damage in the thymus, which finally
impaired the thymic function.