TITLE:
Antibacterial Activities of New Schiff Bases and Intermediate Silyl Compounds Synthesized from 5-Substituted-1,10-phenanthroline- 2,9-dialdehyde
AUTHORS:
Zinia Jaman, Mohammad R. Karim, Korsi Dumenyo, Aminul H. Mirza
KEYWORDS:
5-Nitro-1, 10-phenanthroline Dialdehyde, 5-Bromo-1, 10-phenanthroline Dialdehyde, Schiff Bases, S-Alkyl/Aryldithiocarbazates, Thiosemicarbazide
JOURNAL NAME:
Advances in Microbiology,
Vol.4 No.15,
November
26,
2014
ABSTRACT: Schiff bases are known to possess
anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory,
antimicrobial and antimalarial properties. In this paper antibacterial studies
against variety of plants and human pathogenic bacteria with eight newly
synthesized Schiff bases and several intermediate silyl compounds have been
reported. The antibacterial activities of the synthesized compounds were
primarily determined by paper disc diffusion method. The minimum inhibitory
concentration (MIC) of each compound was also determined by tube dilution
process. Seven different human pathogenic bacteria and eighteen different plant
pathogenic bacteria were used for the antibacterial activity studies. While all
synthesized compounds have shown significant antibacterial activity, one
intermediate silyl compound has shown remarkably high antibacterial property.
5-substituted derivatives have shown relatively higher activity than
non-substituted compounds. Polar substituent which increases hydrophilicity
may have a positive impact on the antibacterial property.