TITLE:
The Differences of Cord Blood Troponin I (TnI) Level between Normal and Asphyxiated Infants and Its Correlation with APGAR Score
AUTHORS:
Amillia Siddiq, Sofie R. Krisnadi, Jusuf S. Effendi
KEYWORDS:
APGAR Score, Asphyxia, Cord Blood Troponin I Level, TnI
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.15,
November
11,
2014
ABSTRACT: Asphyxia could increase
infant morbidity and mortality. Ante- and
intrapartum cardiotocography (CTG) examination could lead to a false positive
diagnosis of asphyxia (fetal distress). Troponin I (TnI) is an important factor
to the pathogenesis of asphyxia. Cord blood TnI level is increased in infants with fetal cardiac dysfunction,
causing pathological CTG and low APGAR score ( TnI level
between normal and asphyxiated
infants and to determine the
correlation between TnI level and APGAR score. An observational
analytical cross sectional study was conducted to a total of 36 patients with asphyxiated infants (18 patients) and normal infants (18 patients). Subjects were selected
according to the inclusion and exclusion criteria. Cardiotocography, TnI level, and APGAR score were examined. Umbilical cord blood samples were
taken from each subject for the measurement of TnIlevel using a highly sensitive indirect sandwich Enzyme Linked
Immunosorbent Assay (ELISA). Statistical analysis was performed by Mann-Whitney and Rank
Spearman correlation coefficient test. Cord blood TnI level of asphyxia andnormal groups were 1615.77
± 1199.98 pg/mL and 819.88
± 145.82 pg/mLrespectively (p ≤
0.05). Rank Spearman correlation coefficient between cord blood TnI level and
1’ and 5’ APGAR score was -0.523 (p = 0.026; p ≤ 0.05)and
-0.502 respectively (p = 0.034; p ≤ 0.05).
There was a statistically significant difference between cord blood TnI level
of asphyxia and normal groups; cord blood TnI level of asphyxia group was
higher than normal group. Furthermore, negative correlation was observed
between cord blood TnI level and APGAR score.