TITLE:
Synthesis and Biological Activity of Drug Delivery System Based on Chitosan Nanocapsules
AUTHORS:
Mohamed Gouda, Usama Elayaan, Magdy M. Youssef
KEYWORDS:
Chitosan, Naproxen, Nanocapsules, Drug Delivery Systems, Antimicrobial, Antioxidant, DNA Degradation
JOURNAL NAME:
Advances in Nanoparticles,
Vol.3 No.4,
November
11,
2014
ABSTRACT: Chitosan nanocapsules
containing naproxen as an active ingredient were synthesized by ionic gelation
method in presence of polyanion tripolyphosphate as a crosslinker. The
morphology and diameter of the prepared chitosan nanoparticles was
characterized using scanning electron microscopy and transition electron
microscopy. Different factors affecting on the size diameter of chitosan nanoparticles
such as stirring time and temperature, pH values as well as chitosan concentration
were studied. Different factors affecting on the immobilization of naproxen
into chitosan nanoparticles such as time, temperature and pH values were
optimized. Synthesized naproxen/chitosan nanocapsules were assessed against
both Gram positive bacterial strain such as Bacillus subtilis and Staphylococcus
aureus and Gram negative bacterial strain such as Pseudomonas aeruginosa and Escherichia coli. Also, the antifungal activity of the
naproxen/chitosan nanocapsules against Saccharomyces cerevisiae was
demonstrated. Super oxide dismutase like activity of naproxen/chitosan
nanocapsules will be determined.