TITLE:
Evaluation of Association between Chlamydophila pneumoniae and Atherosclerotic Plaques in Coronary Artery Disease Patients with Abnormal Angiography
AUTHORS:
Darioush Iranpour, Frahad Abbasi, Kamran Mirzayee, Nahid Mohammadzadeh, Alireza Raeisi, Akram Najafi
KEYWORDS:
Chlamydophila pneumonias, Atherosclerosis, Angiography, Infection
JOURNAL NAME:
Health,
Vol.6 No.18,
October
16,
2014
ABSTRACT: The role of Chlamydophila
pneumoniae in pathogenesis of atherosclerosis is one of the most important
discussions in coronary artery diseases. In this study, the relationship
between C. pneumoniae seropositivity and atherosclerotic plaque was
evaluated among two groups: one group with significant coronary stenosis and
one group with normal coronary angiography. Serum C. pneumonia IgM and
IgG were evaluated and compared in case and control groups. The seropositivity
rates of IgM and IgG antibodies were not statistically differ between case and
control groups, although the incidences of positivity were more in case group.
The results of our study did not show a correlation between C. pneumonia infection and atherosclerotic plaque or coronary artery stenosis neither in
acute nor in chronic infection. More precise studies are needed to clarify the
probable inflammatory cascade that starts with C. pneumonia infection
and lead to development of atherosclerotic plaque.