TITLE:
Evaluation of Lipid Peroxidation and Some Antioxidant Activities in Patients with Primary and Metastatic Liver Cancer
AUTHORS:
Ayse Arslan, Halit Demir, M. Fatih Ozbay, Harun Arslan
KEYWORDS:
Primary and Metastatic Liver Cancer; Lipid Peroxidation; Antioxidant Enzymes
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.2,
February
20,
2014
ABSTRACT:
Abstract: HCC is the 6th most common cancer in the
world. The main risk factors associated with HCC are hepatitis B (HBV) and hepatitis C viral infections and other factors that play a role
in HCC development, include aflatoxin B1 (AFB1) cigarette smoking, and chronic
inflammation. The aim of this study is to investigate lipid peroxidation and
some antioxidant enzyme activities in patients with primary and metastatic
liver cancer. For this purpose, 25 primary and metastatic liver cancer patients
and 15 healthy controls were included in the study. In blood samples taken from the patient and control
groups, the main product of lipid peroxidation MDA and SOD,
GSH, GPx activity levels were examined. In result of study serum MDA level is
higher and erythrocyte SOD, GSH, and GPx activities were found to be
significantly lower in the patient group compared with the control group (p 0.05). As a result, liver cancer is associated with
oxidative stress and antioxidant system weakens, which is an important
indicator of oxidative stress, lipid peroxidation levels increased and promotes
the tissue damage.