TITLE:
Extensive Quantitative Analysis of Gallstones
AUTHORS:
Saadeldin A. Idris, Kamal Elzaki Elsiddig, Aamir A. Hamza, Mohamed M. Hafiz, Mohammed H. F. Shalayel
KEYWORDS:
Cholesterol Stone (CS); Gallstone (GS); Mixed Stone (MS); Pigment Stone (PS)
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.5 No.1,
January
15,
2014
ABSTRACT:
Background: The chemical
composition of gallstones is essential to study aetiopathogenesis of gallstone
disease. Objective: To determine
the composition of gallstones in a Sudanese population. Patients and methods: It describes an extensive quantitative
analysis of gallstones from patients presented with symptomatic gall stone disease and treated by cholecystectomy after the acceptance
of the pre-given informed consent in Khartoum teaching hospital in the period
between Jan 2010 and Dec 2010. Using a pretested questionnaire data collected from
and analyzed statistically by SPSS computer program version 21. Results: Data are analyzed from 94
patients (six males and 88 females). Cholesterol stones showed a
significantly higher cholesterol content than pigment stones (p = 0.0042),
though not significantly higher than mixed stones. Their phospholipids content
and inorganic phosphates were higher than in the other types of stones and
oxalate content was significantly elevated in comparison with mixed stones (p = 0.0402). In mixed stones,
the cholesterol, bile acids, and bilirubin were intermediate between cholesterol
and pigment stones, whereas triglycerides were significantly more than pigment
stones (p = 0.0007). Bilirubin (p = 0.0021)
and bile acids (p = 0.0016) were significantly higher than cholesterol stones
(p = 0.0001) and (p = 0.0001) respectively. However, they contained the lowest
amounts of sodium, potassium, magnesium, and oxalate. In pigment stones,
bilirubin was significantly higher (p = 0.0001) than both groups. Conclusion: Collaborations between
surgeons, nutritionists, biochemists, and physicians should be stimulated in
future studies to define the different types of gall stones in different areas
in Sudan and the relevancy of such types with diets’ traditions.