TITLE:
Investigation of Antidiabetic Effect of Ethanolic Extract of Phyllanthus emblica Linn. Fruits in Experimental Animal Models
AUTHORS:
Zakia Sultana, Safkath Ibne Jami, Ershad Ali, Marium Begum, Mominul Haque
KEYWORDS:
Phyllanthus emblica; Ethanolic Extract; Antidiabetic Effects; Disaccharidase Activity
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.1,
January
6,
2014
ABSTRACT:
Hypoglycemic effects were investigated in the
ethanolic extract of fruits of Phyllanthus
emblica Linn. with long evans rats (100-120 g). Residual gut sucrose content, gut perfusion
and disaccharidase activity studies were carried out to assess these
activities. The residual gut sucrose content study was carried out to reveal
the amount of sucrose remaining in the gastro intestinal tract (GIT) at six
different segments. The ethanolic fruit extract of Phyllanthus emblica Linn. significantly increases the residual
sucrose content throughout the gut after sucrose ingestion. Study on intestinal
enzyme activity showed that the extract caused a significant (p 0.05), dose dependent
inhibition of intestinal disaccharidase enzyme activity. Evaluation of the
effect of the plant extract on intestinal enzyme activity showed significant
inhibition of intestinal disaccharidase activity, suggesting that reduction of
sucrose absorption may be partly related to the inhibition of disaccharidase
activity in the gut. The gut perfusion analysis showed that the extract
significantly reduced intestinal glucose absorption. The results of the present
study suggest that ethanolic extract of Phyllanthus
emblica Linn. has significant antidiabetic effects in a dose dependent manner
and this may be effective in the treatment of diabetes.