M. Hossein Fatemi and S. Gharaghani, “A Novel QSAR Model for Prediction of Apoptosis-Inducing Activity of 4-Aryl-4-H-Chromenes Based on Support Vector Machine,” Bioorganic & Medicinal Chemistry, Vol. 15, No. 24, 2007, pp. 7746-7754. doi:10.1016/j.bmc.2007.08.057

has been cited by the following article:

• TITLE: Using Multiple Linear Regression and Artificial Neural Network Techniques for Predicting CCR5 Binding Affinity of Substituted 1-(3, 3-Diphenylpropyl)-Piperidinyl Amides and Ureas

  AUTHORS: Rokaya Mouhibi, Mohamed Zahouily, Khalid El Akri, Naîma Hanafi

  KEYWORDS: Artificial Neural Network, Descriptors; CCR5; Multiple Linear Regression; Structure-Activity Relationship

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.3 No.1, March 29, 2013

  ABSTRACT: Quantitative structure–activity relationship (QSAR) models were developed to predict for CCR5 binding affinity of substituted 1-(3, 3-diphenylpropyl)-piperidinyl amides and ureas using multiple linear regression (MLR) and artificial neural network (ANN) techniques. A model with four descriptors, including Hydrogen-bonding donors HBD(R7), the partition coefficient between n-octanol and water logP and logP(R1) and Molecular weight MW(R7), showed good statistics both in the regression and artificial neural network with a configuration of (4-3-1) by using Bayesian and Leven-berg-Marquardt Methods. Comparison of the descriptor’s contribution obtained in MLR and ANN analysis shows that the contribution of some of the descriptors to activity may be non-linear.