TITLE:
Use of Escherichia coli toxins in sepsis models
AUTHORS:
Ian Burkovskiy, Juan Zhou, Christian Lehmann
KEYWORDS:
Sepsis; Endotoxemia; Lipopolysaccharide; LPS
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.3A,
March
29,
2013
ABSTRACT:
The
high prevalence of sepsis in intensive care units and emergency rooms, along
with the high lethality of the sepsis cases makes the study of pathophysiology
of sepsis critically important. As a preclinical model, endotoxemia is an
important tool to study the pathophysiology of sepsis and septic shock. In
this review, we discussed aspects of endotoxemia as an experimental model in
sepsis research, including different techniques associated with the
purification of the endotoxin of Escherichia coli, serotype dependency and
dosage dependency of the experimental results.