W. M. Patrick and I. Matsumura, “A Study in Molecular Contingency: Glutamine Phosphoribosyl Pyrophosphate Amidotransferase is a Promiscuous and Evolvable Phosphoribosyl Anthranilate Isomerase,” Journal of Molecular Biology, Vol. 377, No. 2, 2008, pp. 323-336. doi:10.1016/j.jmb.2008.01.043

has been cited by the following article:

• TITLE: Bacterial Cells as Model Factories

  AUTHORS: Ichiro Matsumura

  KEYWORDS: Complex Systems; Control Theory; Synthetic Biology; Metabolic Engineering

  JOURNAL NAME: American Journal of Operations Research, Vol.3 No.1A, January 30, 2013

  ABSTRACT: Bacteria, like industrial engineers, must manage processes that convert low value inputs into high value outputs. Bacteria are not intelligent, so they utilize self-organizing production systems to accelerate life-sustaining chemical processes. Here I explore two questions. First, can businesses apply the principles of self-organization? Second, can operations researchers contribute to our understanding of biological systems? I explain biochemical concepts in plain terms, illustrated with a few informative laboratory evolution experiments, and describe the organizing principles that underlie complex biological systems. I describe the new disciplines of synthetic biology and metabolic engineering, which offer opportunities for interdisciplinary collaboration between life scientists and operations researchers.