Posypanova G. A., Gorokhovets N. V., Makarov V. A., Savvateeva L. V., Kireeva N. N., Severin S. E., Severin E. S., Recombinant alpha-fetoprotein C-terminal fragment: the new recombinant vector for targeted delivery. J Drug Target., vol.16, pp. 321-328, May 2008.

has been cited by the following article:

• TITLE: Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine) Dendrimers and Study of Its Cytotoxic Activity

  AUTHORS: S. I. Kisil, V. A. Chernikov, M. I. Danilevskiy, L. V. Savvateeva, N. V. Gorokhovets

  KEYWORDS: Alpha-fetoprotein; Dendrimer; Doxorubicin; Targeted Delivery

  JOURNAL NAME: Engineering, Vol.4 No.10B, January 17, 2013

  ABSTRACT: The recombinant third domain of alpha-fetoprotein (AFP3D) is one of the promising vectors for targeted delivery of anticancer drugs to tumor cells. AFP3D-based conjugates with various anti-tumor agents have shown specific anti-tumor activity. The content of anti-tumor drugs in the preparation could be increased by including dendrimers - highly branched nanoparticles - into a targeted delivery system. In this study, we synthesized the AFP3D conjugate with doxorubicin-loaded poly(amidoamine) (PAMAM) dendrimer nanoparticles and investigated its cytotoxic activity.