TITLE:
A Novel Vehicle Formulation for Treatment of Inflammatory Skin Diseases
AUTHORS:
A. Zemtsov, H. Hosier
KEYWORDS:
Cetirizine; Antihistamines; Emu Oil; Psoriasis; Eczema; Atopic Dermatitis
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.3 No.1A,
January
10,
2013
ABSTRACT:
Objective: To
test the efficacy of a new topical vehicle formulation containing cetirizine in
emu oil in treating inflammatory skin conditions. Methods: A single blind half body comparative study of patients
with psoriasis, atopic and stasis dermatitis were all treated with midpotency
topical steroid (desoximethasone) in propylene glycol base, desoximethasone and
cetirizine in propylene glycol base, desoximethasone in emu oil base and
desoximethasone with cetirizine dissolved in emu oil. Results: Based on patients’ ranking of creams’ efficacy, and
supported by photographic data and investigators’ clinical assessment, results
clearly indicated that desoximethasone and cetirizine in emu base was statistically
more efficacious than either desoximethasone alone or with cetirizine in
neutral propylene glycol base or desoximethasone in emu oil base (without
cetirizine). Conclusions: Cetirizine
and emu oil, having inherent anti-inflammatory and other beneficial properties
synergistically, and by different biochemical pathways, enhance and magnify
each other’s pharmaceutical effects that are useful in treatment of skin
inflammatory diseases.