TITLE:
Synthesis and Biological Evaluation of a Highly Constrained Analogue of Methylthioadenosine (MTA)
AUTHORS:
Gustavo Senra G. de Carvalho, Rafael Mafra de P. Dias, Jean-Louis Fourrey, Vânia L. Silva, Cláudio G. Diniz, Adilson D. da Silva
KEYWORDS:
Synthesis; Biological Evaluation; Antibacterial; Analogue Methylthioadenosine
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.4,
December
28,
2012
ABSTRACT: We describe the synthesis and the antibacterial evaluation 2’,N3-cyclonucleoside 3 analogue of MTA that is characterized by the presence of an additional linkage between the heterocyclic ring and the sugar moiety.