TITLE:
Ultrasonically Assisted Synthesis of Aromatic Sulfonic Acids under Vilsmeier Haack Conditions in Acetonitrile Medium
AUTHORS:
Kamatala Chinna Rajanna, Purugula Venkanna, Mukka Satish Kumar, Soma Ram Gopal
KEYWORDS:
Vilsmeier Haack (VH) Reagent; Sulfonation; NaHSO3; Sonication; Aromatic Compounds
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.4,
December
27,
2012
ABSTRACT: Sulfonation of aromatic compounds (Phenols, Anilines) is triggered by Vilsmeier Haack (VH) reagent (DMF/POCl3) or (DMF/SOCl2) in the presence of NaHSO3 under Sonication and conventional stirred conditions at room temperature. The reactions afforded corresponding Sulfonic acid derivatives in very good yields. The results obtained under Sonication were enhanced when compared with the yields of the conventional method.