M. Gotthardt, B. Lohmann, T. M. Behr, A. Bauhofer, C. Franzius, M. L. Schipper, M. Wagner, H. Hoffken, H. Sitter, M. Rothmund, K. Joseph and C. Nies, “Clinical Value of Parathyroid Scintigraphy with Technetium-99m Methoxyisobutylisonitrile: Discrepancies in Clinical Data and a Systematic Metaanalysis of the Literature,” World Journal of Surgery, Vol. 28, No. 1, 2004, pp. 100-107. doi:10.1007/s00268-003-6991-y

has been cited by the following article:

• TITLE: Additional Imaging Following a Negative Sestamibi Scan in Primary Hyperparathyroidism

  AUTHORS: Bas Twigt, Anne Vollebregt, Piet de Hooge, Alex Muller, Thijs van Dalen

  KEYWORDS: Imaging-Primary Hyperparathyroidism-Sestamibi Scan-Ultrasound-CT

  JOURNAL NAME: International Journal of Otolaryngology and Head & Neck Surgery, Vol.1 No.3, November 29, 2012

  ABSTRACT: Background: The objective of this study was to assess the additional yield of US and CT following a “negative” initial MIBI-scintigraphy (MIBI) in patients with primary hyperparathyroidism. Methods: Prospective data were collected regarding 100 consecutive patients, preferentially undergoing a minimally invasive parathyroidectomy (MIP). MIBI was the initial imaging study for localizing a solitary adenoma, followed by US and CT (US/CT) in “MIBI-negative”-patients. Results: Surgery led to normocalcemia in 98 patients (98%) after one operation. Overall 97 patients had solitary parathyroid disease while three patients had multiglandular disease. The sensitivity of imaging increased from 74% for MIBI alone to 92% following subsequent US/CT in “MIBI-negative”-patients. The positive predictive value of a “positive” MIBI was 96% and 76% of a positive US/CT following negative MIBI. The proportion of patients who underwent successful MIP increased from 60 to 72%. Conclusions: MIBI and the combination of US and CT are complementary imaging studies. Additional localization studies after a negative sestamibi scan enhances the number of patients with primary hyperparathyroidism profiting from a minimally invasive approach.