Article citationsMore>>
L. V. Christensen, C. W. Chang, W. J. Kim, S. W. Kim, Z. Zhong, C. Lin, J. F. J. Engbersen and J. Feijen, “Reducible Poly(Amido Ethylenimine)s Designed for Triggered Intracellular Gene Delivery,” Bioconjugate Chemistry, Vol. 17, No. 5, 2006, pp. 1233-1240. doi:10.1021/bc0602026
has been cited by the following article:
-
TITLE:
Reducible Poly (2-Dimethylaminoethyl) Methacrylate-Block-Polyvinylimidazole: Synthesis, Transfection Activity in Vitro
AUTHORS:
Bozhang Yu
KEYWORDS:
Reducible Polymer; Gene Expression; Transfection; Cytotoxicity
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.3 No.1,
January
12,
2012
ABSTRACT: Reducible or imidazolyl polycations of block poly(imidazole/2-dimethyl aminoethyl) are of promising in gene delivery. Dimeric poly(2-dimethyl aminoethyl) methacrylate-block-polyvinylimidazole (rDPDMAEMAIM) and reducible poly (2-dimethylaminoethyl) methacrylate (rDPDMAEMA) with single disulfide bond in the backbone was synthesized by oxidizing their dithioester-terminated polymers. The polyplexes sizes, rDPDMAEMAIM/pDNA and rDPDMAEMA/ pDNA (plasmid DNA) are in the ranges of 100 nm - 150 nm at the weight ratio of 12:1, and the zeta potential of rDPDMAEMAIM/pDNA from 9.6 mV to 22.7 mV in PBS solutions increases with their weight ratios of 1:1 to 18:1. The results show that the rDPDMAEMAIM/pDNA polyplexes have higher transfection activity and lower cytotoxicity than that of rDPDMAEMAIM/pDNA against 293T cells in vitro in the presence of serum, indicating that the PDMAEMAIM present a promising nonviral gene vector.
Related Articles:
-
Moawwad E. A. El-Mikkawy
-
Jai Dev Chandel, Nand Lal Singh
-
Ngozi Grace Emordi, Iweriolor Sunday, Onyekpe Basil Obimma
-
Casimir Komenan
-
Julien Celestine, Arnaud Tanti, Arnaud Aubert