Lisic, E., Grossarth, S., Bowman, S., Hill, J., Beck, M., Deweese, J. and Jiang, X. 2022) New Copper(II), Palladium(II), and Platinum(II) 2-Acetylpyrazine Tert-Bu-tylthiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells. Open Journal of Medicinal Chemistry, 12, 1-13.
https://doi.org/10.4236/ojmc.2023.121001

has been cited by the following article:

• TITLE: Synthesis and Physico-Chemical Characterizations of Novel Hydrazone Ligands and Their Metal Complexes against Hormone-Dependent and Independent Cancers

  AUTHORS: Sommai Patitungkho, Kingkaew Patitungkho

  KEYWORDS: Metal Complexes, Cancers, Antioxidant, Hydrazone, Retinoid Receptors

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.14 No.1, March 29, 2024

  ABSTRACT: This work deals with the synthesis and physicochemical characterizations of a new group of novel retinoidal ligands and their metal complexes. Their in vitro anti-proliferative activities have shown that ligand L1 is effective against human breast cancer BT-20 and MCF-7 cell lines. At the same time, compound L2 exerts its effect on human prostate cancer PC-3 and human breast cancer MDA-MB-231 and MCF-7 cell lines respectively. The retinoid ligands exert their pleiotropic action toward retinoic acid receptors (RARs) than their metal complexes but all compounds exhibit concentration-dependent.