TITLE:
Serum Immunoglobulin Concentrations in Juvenile Idiopathic Arthritis Cases during Active and Inactive Disease States
AUTHORS:
Sajib Muhammad Rayhan, Kamrul Laila, Shahana A. Rahman
KEYWORDS:
JIA, Oligoarticular JIA, Polyarticular JIA, Immunoglobulins, Acitive Disease, Inactive Disease
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.14 No.2,
March
27,
2024
ABSTRACT: Background: Juvenile idiopathic arthritis (JIA) is the most
common rheumatic disease in children.
Both the humoral and cell mediated immunities are involved in the pathogenesis of JIA. It is
reported that overall immunoglobulin levels in JIA patients are significantly
higher than their control during the active state of disease. Methodology: This
prospective observational study was conducted over a period of 18 months All
the newly diagnosed oligo-articular and poly-articular JIA patients having
active disease were included by purposive sampling. Data were collected by a
semi-structured predesigned questionnaire. Result: Most of the study
subjects (57.6%) belonged to age group > 3 - 9 years. Oligo JIA was diagnosed in 66.7% and
poly JIA in 33.3% of JIA
children. The difference in mean
(±SD) ESR (33.52 ± 21.29 and 15.09 ± 7.71 mm in 1st hour) at active and inactive states was highly significant. Mean
(±SD) difference of IgG, IgM and IgA in active and inactive states of disease were highly
significant. Conclusion: Higher and abnormal levels of immunoglobulin
(IgG, IgM, and IgA) were present among JIA patients in active disease state which became normal during
inactive disease state after treatment.