TITLE:
Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic Resistance in Pseudomonas aeruginosa PAO1
AUTHORS:
Godspower Oghenemaroh Sebe, Supreme O. Oghenerhoro, Ogbole E. Jonathan, Ebuka Victor Anyaogu, Adeyemo David Adebowale, Raymond Chidozie Ntomchukwu
KEYWORDS:
Pseudomonas aeruginosa PAO1, Antibiotic Resistance, Next-Generation Antibiotics, Adjuvant Synergy, Intracellular Accumulation, Penetration Rates, Minimum Inhibitory Concentration (MIC), Resistance Tra-jectory, Fluorescence Quantification
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.16 No.8,
August
30,
2023
ABSTRACT:
This study explores the efficacy of
advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B,
an enhanced derivative of Ceftriaxone. The study measured the intracellular
uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which
augmented its antibacterial activity. Results showed a diminished potential for
resistance emergence with Antibiotic B, particularly when used in combination
with Influximax. The study suggests that optimizing antibiotic delivery into
bacterial cells and leveraging syner-gistic adjuvant combinations can enhance
drug resistance combat.