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has been cited by the following article:

• TITLE: Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic Resistance in Pseudomonas aeruginosa PAO1

  AUTHORS: Godspower Oghenemaroh Sebe, Supreme O. Oghenerhoro, Ogbole E. Jonathan, Ebuka Victor Anyaogu, Adeyemo David Adebowale, Raymond Chidozie Ntomchukwu

  KEYWORDS: Pseudomonas aeruginosa PAO1, Antibiotic Resistance, Next-Generation Antibiotics, Adjuvant Synergy, Intracellular Accumulation, Penetration Rates, Minimum Inhibitory Concentration (MIC), Resistance Tra-jectory, Fluorescence Quantification

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.16 No.8, August 30, 2023

  ABSTRACT: This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which augmented its antibacterial activity. Results showed a diminished potential for resistance emergence with Antibiotic B, particularly when used in combination with Influximax. The study suggests that optimizing antibiotic delivery into bacterial cells and leveraging syner-gistic adjuvant combinations can enhance drug resistance combat.