TITLE:
Cohort Study on Benefit of Martial Supplementation with EDTA Sodium Iron in Management of Gravidic Anemia at the University Clinics of Kinshasa
AUTHORS:
Andy Muela Mbangama, Ndombasi Nelda Lemba, Ambis Joëlle Lumaya, Nkongolo Freddy Muamba, Banza Jésual Lotoy, Mubalamata Eugène-Patrick Lukusa, Nkashama Bienvenu Kazadi, Otem Christian Ndesanzim, Feruzi Michel Mangala
KEYWORDS:
Anemia, Pregnancy, EDTA Sodium Iron, Martial Supplementation
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.13 No.10,
October
25,
2023
ABSTRACT: Background: Anemia is mainly attributed to nutritional deficiency, especially iron deficiency,
which predominates during pregnancy, and is associated with parasitic diseases
such as malaria and intestinal parasitosis, acute or chronic diseases such as
sickle cell disease, tuberculosis, HIV infection and various micronutrients
disorders. It is associated with an increased risk of low birth weight and
prematurity and can contribute to impaired cognitive development in early
childhood, as well as to maternal mortality. The impact on the fetus is even
greater if maternal anemia onset is at an early stage, or prior to pregnancy.
Iron salts, such as sulfate or fumarate, are widely used in the treatment of gravidic anemia, but due to various
gastrointestinal side effects, many pregnant women are not compliant
with treatment. Sodium iron EDTA, on the other hand, is highly absorbable and
bioavailable. The latter improves hematological values and appears to be free
from the usual iron-related side effects, hence compliance with this
supplementation. Objectives: To evaluate the evolution of hemoglobin
levels after sodium iron EDTA supplementation at the university Clinics of
Kinshasa, to determine the frequency of gravidic anemia, the dose-dependent
benefit of sodium iron EDTA supplementation in pregnant women and to identify
factors associated with insufficient hemoglobin gain after supplementation. Methods:
This longitudinal cohort will take place in the gynecology department of the
University Clinics of Kinshasa from September 2022 to August 2023 and will
include at least 54 pregnant women with anemia. Conclusion: The study
will enable us to better assess the benefits of sodium iron EDTA in improving
hematological values, as well as its tolerability in pregnant women suffering
from anemia during pregnancy in our environment.