TITLE:
Study on the Anti-Inflammatory and Analgesic Mechanisms of Breast Lump Resolution Detergent in a Rat Model of Breast Hyperplasia
AUTHORS:
Chunying Huang, Yun He, Di Ouyang, Xuhui Zhao
KEYWORDS:
Breast Hyperplasia, Breast Lump Resolution Detergent, Estradiol (E2), Prolactin (PRL), Progesterone (P), Anti-Inflammatory, Analgesic
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.13 No.7,
July
31,
2023
ABSTRACT: Objective: This
study aimed to investigate the anti-inflammatory and analgesic mechanisms of a breast lump resolution
detergent in a rat model of breast hyperplasia. Methods: A rat model of
breast hyperplasia was established using injections of estradiol benzoate
combined with progesterone. The effects of the breast lump resolution
detergent on nipple height and diameter in the rat model were observed, along
with its impact on serum levels of estradiol
(E2), prolactin (PRL), and progesterone (P). Additionally, the study examined
the morphological changes in breast tissue. The impact of the breast
nodule detergent on blood rheology parameters was also observed. Furthermore, the anti-inflammatory effect of the breast
nodule detergent was assessed using the cotton ball granuloma
experiment, and the analgesic effect was observed using the writhing test. Results: The breast lump resolution detergent reduced nipple height and diameter in
the rat model, decreased serum levels of E2, PRL, and P, and alleviated
pathological changes in breast tissue. It also lowered hemorheological
parameters including whole blood high, medium, and low shear viscosity, plasma
viscosity, red blood cell hematocrit, red blood cell aggregation index, red
blood cell deformability index, red blood cell electrophoresis time, and
erythrocyte sedimentation rate in the acute “blood stasis” rat model. The
detergent reduced the weight of cotton ball granulomas in mice and decreased the number of writhing episodes
caused by acetic acid. Conclusion: The breast lump resolution detergent
demonstrates favorable therapeutic
effects in treating breast hyperplasia, promoting blood circulation and
removing blood stasis, exerting anti-inflammatory properties, and providing analgesic effects. The downregulation of serum E2
and PRL levels and the upregulation of P levels may be critical
mechanisms underlying its efficacy.