TITLE:
Glomerular Filtration Rate of Children with Sickle Cell Disease Compared to Non-Sickle Cell Patients in Donka Pediatric Emergencies and SOS Drepano-Guinea Center
AUTHORS:
Mohamed Lamine Diallo, Emmanuel Camara, Mamadou Moustapha Diop, Mamadou Cire Barry, Fatoumata Binta Diallo, Aissata Barry, Saliou Bellanrcisse Diallo, Narcisse Idohou, Ganin Paul Ulrich N’dri N’gotta, Mamdy Dramé, Telly Sy, Mohamed Lamine Kaba
KEYWORDS:
Flow, Filtration, Glomerular, Child, Sickle Cell Disease
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.13 No.4,
July
26,
2023
ABSTRACT: Introduction: Our study focused on the
evaluation of renal function in children with sickle cell disease compared to children without sickle cell
disease at the pediatric emergency unit of the Donka National Hospital and SOS
Drepano-Guinea center. Patients and Methods: This was a cross-sectional
descriptive and analytical study lasting 3 months (October 1 to December 31,
2020). Were included, all sickle cell and non-sickle cell children aged 0 to 15
received on an outpatient basis and had undergone an exploration of renal
function (serum creatinine and urine dipstick). Results: We performed
the urine dipstick and serum creatinine in 75 children, 45 of whom were sickle
cell and 30 were not sickle cell. 27 of our patients or 36% had a reduction in
GFR, among them 9 or 20% were sickle cell and 18 or 60% were not sickle cell.
The most affected age group was 5 to 9 years in sickle cell (66.7%) and
non-sickle cell (38.9%). In sickle cell patients, 9 cases (100%) had mild renal
failure (IRL). Non-sickle cell patients, had 14 cases or 77.8% of IRL and 4
cases (22.2%) of moderate IR. Sickle cell disease and antibiotics which had the
respective p-value (0.01); (0.02), were statistically significant with the
onset of renal failure. Conclusion: Several factors including sickle
cell anemia and antibiotics are believed to be involved in lowering GFR. It
would be essential to detect early the children received in consultation.