TITLE:
Confocal Laser Endomicroscopy in the Field of Esophageal Diseases
AUTHORS:
Peiting Xue, Xiuli Zuo
KEYWORDS:
Confocal Laser Endomicroscopy (CLE), Barrett’s Esophagus (BE), High-Grade Dysplasia (HGD), Esophagus Cancer (EC), Gastroesophageal Reflux Disease (GERD)
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.14 No.6,
June
28,
2023
ABSTRACT: Confocal laser endomicroscopy (CLE) is a new endoscopic imaging
technology that allows real-time, high-resolution observation of tomographic
images of mucosal cells and subcellular
levels in vivo, detecting microscopic
structural changes in mucosal morphology, and its in vivo immediate pathological diagnostic
capability can avoid delays in mucosal pathological diagnosis and reduce the pain caused by repeated biopsies. CLE is known as “optical biopsy” and
compared with other endoscopic techniques, it has
obvious advantages. CLE
systems include probe-based confocal laser endomicroscopy (pCLE) and
endoscope-based confocal laser endomicroscopy (eCLE). Since 2006, CLE has been widely used for the
evaluation of various lesions in the digestive system, including esophageal, gastric, and colonic neoplasia,
pancreatic cysts and solid lesions, and inflammatory bowel disease. The advent
of CLE has made in vivo microscopic
imaging possible, which has changed the endoscopic screening and diagnosis of multiple
gastrointestinal (GI) lesions. However,
the value of its use in GI diseases is still controversial. In this review, we
focus on the application of CLE in the field of esophageal diseases.