TITLE:
Endocrine-Disrupting Chemicals: Possible Genesis of Ovarian Tumors
AUTHORS:
Kasonde Chanda, Ziwei Wang, Shen Ning, Xue Bin, Yingxiao Yan
KEYWORDS:
Environmental Toxicants, Endocrine-Disrupting Chemical, Ovarian Cyst, Ovarian Tumor
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.13 No.6,
June
15,
2023
ABSTRACT: Background: Prolonged exposure to environmental toxicants like endocrine-disrupting chemicals has been linked to
several ovarian pathologies. Exposure
to endocrine-disrupting chemicals may start at any time of life from the fetal stage to adulthood resulting in various health
complications The purpose of our
study is to compare the concentration levels and association of benzopyrene, bisphenol A and genistein in patients with ovarian tumors and
normal control group. We also sort to evaluate the predictive performance of
benzopyrene, bisphenol A and genistein in patients with ovarian tumors. Methods: A case-control study was conducted for randomly selected
participants involving 30 patients and 30 controls. 30 patients
with radiologically diagnosed and histopathological
confirmed ovarian tumors were included in the study between January 2022
and December 2022. Urine samples from each group were analyzed using liquid chromatography-mass spectrometry. Descriptive analysis for normally distributed continuous
variables was done accordingly. Concentration levels of endocrine-disrupting
chemicals were assessed using the Mann-Whitney test. The association of endocrine-disrupting chemicals with pathological ovarian tumors was
analyzed using binary logistic regression. Evaluation of the diagnostic performance of endocrine-disrupting chemicals was analyzed using the ROC curve. Results: Overall,
patients were significantly (P = 0.000)
older than the healthy controls. Mean years (SD) were 36.7 (7.90) and 28.8 years (4.89) for patients and
normal women respectively. Endometriomas
had the highest incidence of 50%. The level of benzopyrene and bisphenol A in patients was significantly
higher than those in the control group, while the level of genistein was significantly higher in normal controls.
Benzopyrene and bisphenol A were
significantly associated with ovarian cysts, and the incidence of pathological ovarian cysts was positively
correlated to these EDCs, with OR value 64.79 (P = 0.005) for benzopyrene and 9.609
(P = 0.001) for bisphenol A.
Genistein was significantly negatively correlated with the incidence of pathological ovarian tumors, with OR value of 0.153 (P = 0.007). Diagnostic
performance on the AUC for benzopyrene, bisphenol A and genistein&l