Claus, C., Ferrara, C., Xu, W., Sam, J., Lang, S., Uhlenbrock, F., Albrecht, R., Herter, S., Schlenker, R., Hüsser, T., Diggelmann, S., Challier, J., Mossner, E., Hosse, R.J., Hofer, T., Brunker, P., Joseph, C., Benz, J., Ringler, P., Stahlberg, H., Lauer, M., Perro, M., Chen, S., Küttel, C., Mohan, P.L.B., Nicolini, V., Birk, M.C., Ongaro, A., Prince, C., Gianotti, R., Dugan, G., Whitlow, C.T., Solingapuram. S.K.K., Caudell, D.L., Burgos-Rodriguez, A.G., Cline, J.M., Hettich, M., Ceppi, M., Giusti, A.M., Crameri, F., Driessen, W., Morcos, P.N., Freimoser-Grundschober, A., Levitsky, V., Amann, M., Grau-Richards, S., von Hirschheydt, T., Tournaviti, S., Molhoj, M., Fauti, T., Heinzelmann-Schwarz, V., Teichgraber, V., Colombetti, S., Bacac, M., Zippelius, A., Klein, C. and Umana, P. (2019) Tumor-Targeted 4-1BB Agonists for Combination with T Cell Bispecific Antibodies as Off-the-Shelf Therapy. Science Translational Medicine, 11, eaav5989.
https://doi.org/10.1126/scitranslmed.aav5989

has been cited by the following article:

• TITLE: Construction of Multi-Specific Antibody by Genetic Engineering and Its Progress in Tumor Therapy

  AUTHORS: Zhenqi Xu, Can Gao, Mengru Jian, Wei Du

  KEYWORDS: Genetically Engineered, Multi-Specific Antibody, Tumor Therapy

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.3, March 24, 2023

  ABSTRACT: Targeted treatment of cancer with monoclonal antibodies increases the benefit for patients. In order to improve the anti-tumor activity of monoclonal antibodies, multi-specific antibodies have entered the research field. The emergence of various techniques to produce multi-specific recombinant antibody molecules has led to the selection of target combinations in various forms. To date, only a few multi-specific constructs have entered phase III clinical trials, in contrast to classical monoclonal antibodies. Some of the format options are outlined from a technical point of view. We focus on the achievements and prospects of the underlying technologies for generating biand multispecific antibodies.