Patel, S.R., Hartwig, J.H. and Italiano Jr. J.E. (2005) The Biogenesis of Platelets from Megakaryocyte Proplatelets. The Journal of Clinical Investigation, 115, 3348-3354. https://doi.org/10.1172/JCI26891

has been cited by the following article:

• TITLE: Platelets Play an Integral Role in Body Heat Production and Maintenance: A Newly Proposed Function

  AUTHORS: Thirugnana Subramanian

  KEYWORDS: ADP, ATP, Oxidative Phosphorylation, Platelets, Reactive Oxygen Species

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.3, March 10, 2023

  ABSTRACT: In platelets, most of the ADP is stored in dense granules and released into extracellular space through exocytosis as a signaling molecule upon platelet activation. Glycolysis and the TCA cycle consume considerable amounts of ADP; however, limiting quantities of available ADP to make ATP through OXPHOS result in failure of ATP production and release of energy as heat into the surroundings. Thus, body heat may be a potential product of circulating platelets. Furthermore, the incomplete OXPHOS process causes the production of ROS that leads to earlier platelet death resulting in shorter life span. In the future, this new function may have a wide variety of clinical applications.