TITLE:
Synthesis and Antitumor Activity of 3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[d] Isoxazole-4,6-Diol
AUTHORS:
Li Wang
KEYWORDS:
3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[d] Isoxazole-4, 6-Diol, Synthesis, Antitumor Activity
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.13 No.1,
February
3,
2023
ABSTRACT: A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characterized by 1H NMR, 13C NMR and HR-MS. The phloretin, compound 1, resveratrol and acetylated resveratrol were determined by comparing them with paclitaxel. Anti-tumor activity of alcohol on SPC-A1, EC109, A549, MCF-7 and MDA-MB-231 cell lines. Compound 1 showed better antitumor activity than docetaxel against A549 tumor cells.