TITLE:
Drug Resistance in Malaria Parasites: Does “Specific Antidrug Substance” Exist?
AUTHORS:
Gao-De Li
KEYWORDS:
Molecular Pharmacology, Drug Resistance in Malaria Parasite, “Specific Antidrug Substance”, 3D Genome Architecture, “Specific Antidrug Group of Protein Combinations”
JOURNAL NAME:
Open Access Library Journal,
Vol.10 No.1,
January
31,
2023
ABSTRACT: Development of drug-resistant lines in rodent malaria parasites left us a deep impression on antidrug specificity of antimalarial drug-resistant lines, which is similar to antigen-induced antibody. Based on this comparison, “specific antidrug substance” was proposed to explain antidrug specificity of drug-resistant lines. If “specific antidrug substance” refers to a protein that is quite like antibody, the concept of “specific antidrug substance” is wrong because no such protein has been discovered. However, if “specific antidrug substance” refers to a “specific antidrug group of protein combinations”, the concept of “specific antidrug substance” might be true. A detailed explanation of “specific antidrug substance” is presented in this paper.