TITLE:
Epidemiological Aspects and Results of the Management of Polycystic Ovary Syndrome at the CNHU-HKM of Cotonou
AUTHORS:
Annelie Kerekou Hode, Justin Lewis Denakpo, Dedjan A. Hubert, Mohamed Dakin, Esther Techeme
KEYWORDS:
Hirsutism, Spaniomenorrhea, Hyperandrogenism, Insulin Resistance, Metformin
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.12 No.12,
December
30,
2022
ABSTRACT: Introduction: Polycystic Ovarian Syndrome (PCOS), also known as Stein Leventhal
Syndrome, is one of the common endocrine diseases affecting women of
childbearing age and the leading cause of anovulatory infertility worldwide. The
aim of this study was to describe the clinical, paraclinical and therapeutic
aspects of PCOS at the University Clinic of Obstetrics and Gynaecology of the
National Hospital and University Centre Hubert Koutoukou MAGA of Cotonou
(CNHU). Patients and Method: The study was doing in the University
Clinic of Gynecology and Obstetrics of the CNHU-HKM. This was a descriptive and
analytical longitudinal study with retrospective and prospective data
collection over a period of 7 years from January 2015 to December 2021. It
focused on women of childbearing age seen in gynecological consultation. Results: The frequency of PCOS was 2.53%. The mean age of the patients was 27.28 ±
6.55 years. They were educated for the most part with a university level in
43.8% of cases. Obstetrically they were nulligest (45.63%) and nulliparous in
60% of cases. The history of spontaneous miscarriages was found in 61.11%. The
main reasons for consultation were menstrual disorders (51%) followed by the
desire for pregnancy (40.6%). Clinically, obesity (30%), overweight (33.1%),
high blood pressure (20.63%), hirsutism (24%) and acne (27%) were noted. All
the women had micropolycystic ovaries in ultrasound. Testosterone was elevated
in 61% of cases. Phenotype D was found in 45.63% of patients. All these
patients were put under lifestyle and dietary measures, Metformin (13.80%) and
estrogen-progestogen (18.80%). The outcome of the treatment was assessed by
cycle regularity, regression of hirsutism, weight loss, fertility and
fertility. The cycle was normalised in most cases with notable regression of
physical signs of hyperandrogenism. The cycle was normalized in most cases with the
notable regression of physical signs of hyperandrogenism. We had recorded 25
pregnancies including one miscarriage. The occurrence of pregnancy was obtained
in 50% of these women after 12 months and in less than 20% after 24 months. Conclusion: PCOS was common in the CUGO of the CNHU-HKM. A population-based
epidemiological study seems necessary to better appreciate the risk factors of
this endocrine syndrome and its repercussions on fertility and metabolic
diseases such as type 2 diabetes, obesity and hypertension.