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has been cited by the following article:

• TITLE: Experimental Study on the Treatment of Gallbladder Distention by Dahuang Lingxian Prescription

  AUTHORS: Xin Huang, Xiaowei He, Yirong Gan, Bing Wang, Man Zhang, Jianye Dai, Yuan Yu

  KEYWORDS: Gallbladder Distention, Dahuang Lingxian Prescription, Cell Ultrastructure, Signal Transduction, Traditional Chinese Medicine

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.10 No.11, November 16, 2022

  ABSTRACT: Objective: To investigate the mechanism of inhibiting the secretion of “lithogenic bile” and treating gallbladder distention with the TCM prescription Dahuang Lingxian. Methods: Forty SPF-grade SD male mice were randomly divided into blank control group, model group, ursodeoxycholic acid group and TCM group, 10 mice in each group. The blank control group was kept normally, and the model group, ursodeoxycholic acid group and TCM group were established as gallbladder distention models. The blank control group and the model group were given 1.5 ml of saline by gavage daily; the ursodeoxycholic acid group was given 100 mg/kg/d of a mixture of saline and ursodeoxycholic acid capsules by gavage daily; the TCM group was given 39 g/kg/d of aqueous decoction of Dahuang Lingxian Prescription by gavage daily. After 6 weeks of continuous intervention, all mice were executed and the lithogenesis rate, ultrastructure and mRNA expression were observed. Results: The lithogenesis rate of mice in the TCM group was significantly reduced (P β1/Smads pathway was significantly improved (P