TITLE:
Short-Chain Fatty Acids-A Healthy Bus between Gut Microbiota and Organs beyond the Gut
AUTHORS:
Ruyue Cao, Yunqing Zeng, Shuhua Li, Peiting Xue, Ming Li
KEYWORDS:
Short-Chain Fatty Acids, Gut Microbiota, Extraintestinal Organs, Immune Regulation, Diet
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.13 No.9,
September
14,
2022
ABSTRACT: The impact of the gut microbiota is not limited to
the intestine, but its interaction with the host produces active metabolites,
which can be transported by the blood circulation to play important roles in
various parts of the body. Among them, short-chain fatty acids (SCFAs), as
important active products of gut bacteria, have been shown to exert
anti-inflammatory and immunomodulatory effects and can play active roles as
signaling molecules in the development of various intestinal and extraintestinal
diseases, such as inflammatory bowel disease, colon cancer, multiple sclerosis,
hypertension, allergic airway disease, obesity, diabetes, kidney disease,
rheumatoid arthritis, etc. In this way, modulation of the intestinal microbiota
and metabolism-active substances has gradually become a popular therapeutic method for many
diseases of organs beyond the gut. To find new therapeutic targets for major
human health problems, this article reviews the research on SCFAs in
extraintestinal diseases.