Article citationsMore>>
Jackson, R.D., LaCroix, A.Z., Gass, M., Wallace, R.B., Robbins, J., Lewis, C.E., Bassford, T., Beresford, S.A.A., Black, H.R., Blanchette, P., Bonds, D.E., Brunner, R.L., Brzyski, R.G., Caan, B., Cauley, J.A., Chlebowski, R.T., Cummings, S.R., Granek, I., Hays, J., Heiss, G., Hendrix, S.L., Howard, B.V., Hsia, J., Hubbell, A., Johnson, K.C., Judd, H., Kotchen, J.M., Kuller, L.H., Langer, R.D., Lasser, N.L., Limacher, M.C., Ludlam, S., Manson, J.E., Margolis, K.L., McGowan, J., Ockene, J.K., O’Sullivan, M.J., Phillips, L., Prentice, R.L., Satro, G.E., Stefanick, M.L., Van Horn, L., Wactawski-Wende, J., Whitlock, E., Anderson, G.L., Assaf, A.R. and Barad, D. (2006) Calcium Plus Vitamin D Supplementation and the Risk of Fractures. The New England Journal of Medicine, 354, 669-683.
https://doi.org/10.1056/NEJMoa055218
has been cited by the following article:
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TITLE:
Bone Health in Pediatric Fracture Patients: A DEXA Study
AUTHORS:
Barbara Minkowitz, Jennifer Ristic, Leah Nadel, Meghan McDermott, Violet Wallerstein, Eileen Poletick
KEYWORDS:
Bone Health, Pediatric, Fracture, Vitamin D, DEXA, Osteoporosis, Osteopenia, Vitamin D Deficiency
JOURNAL NAME:
Open Journal of Orthopedics,
Vol.12 No.2,
February
23,
2022
ABSTRACT: Vitamin D deficiency is widespread in children and is associated with
increased fracture severity. Previous studies have shown mixed results on the
impact of vitamin D supplementation on bone
health parameters measured on dual-energy x-ray absorptiometry (DEXA) scan.
This is the first longitudinal DEXA study in a pediatric fracture population.
Pediatric fracture patients with vitamin D levels below 20
ng/mL were counseled to take vitamin D and calcium per a serum-based protocol.
Patients underwent baseline DEXA within the initial 12 weeks post fracture and
had follow-up scans at 6 and 12 months. 48 patients were enrolled, 32 patients
completed two DEXA scans, and 19 completed three DEXA scans. There was a
significant increase in lumbar spine BMC,
TBLH BMD, and TBLH BMC between DEXA 1 and 2 (p 0.001). A
positive trend in DEXA parameters is suggested between DEXA 1 and DEXA 3.
Height adjusted z-scores (HAZ) were calculated which showed no statistical significance,
p-values > 0.05. In this group, there are no significant changes in TBLH, BMC or BMD
z-scores one year after fracturing despite
vitamin D and calcium supplementation. This suggests that children returning to
collision sports may be at continued risk for refracture and future studies are
needed.
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