TITLE:
Frequency and Antimicrobials Susceptibility Pattern of Staphylococcus aureus Associated with Wound Infections in Surgery Department, Wad Madani Teaching Hospital, Sudan
AUTHORS:
Sanaa M. Yousif, Adam D. Abakar, Bakri Y. M. Nour, Salma O. Ibrahim, Omer M. Abu Elhasan, Mirgani A. Yousif, Sitelbanat Yassin, Hajer M. Hussien, Mohamed Taj-Eldin, Elhadi A. Ahmed
KEYWORDS:
Staphylococcus aureus, Surgical-Sites, Wounds, Meropeneme, Sudan
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.12 No.12,
December
30,
2021
ABSTRACT: Background: Most community and hospital acquired infections are due to Staphylococcus
aureus, these infections involve both local suppurative and systemic
conditions. There is an increase in the
incidence rates of acquiring resistant strains of Staphylococcus aureus in hospitals and community in Sudan. This study aims to detect frequency of Staphylococcus
aureus isolated from surgical-sites infections (SSIs) and traumatic wounds,
and to determine susceptibility to commonly used drugs. Methods: Prospective
cross-sectional laboratory based study was followed, 250 patients admitted to
Surgery Departments at Wad Madani Teaching Hospitals during 2019 and 2020 were
recruited; with clinical manifestation of SSIs and or/traumatic wounds. Swab
sample was taken from each participant and incubated aerobically on mannitol
salt agar. Biochemical tests and 16rRNA gene used for Staphylococcus aureus identification. Antimicrobial susceptibility was accomplished using Kirby Bauer
disc diffusion technique. Results: Infection rate of wounds in males and
females equal 71% (17/250) and 29% (73/250), while infection rate in the age
group of 41 to 60 years was the highest with percentage of 49% (122/250). Staphylococcus
aureus constituting 76% (181/238) as predominant isolates. SSIs isolates of Staphylococcus aureus were highly
resistant to tested antimicrobials. Meropeneme was the drug of choice with
sensitivity of 88% and 100% for SSIs and traumatic wounds isolates
respectively. Conclusion: In hospitals and community Staphylococcus
aureus remain the most common cause of wounds infections. The high
resistance to used drugs shown by Staphylococcus aureus in this study
requires an assessment of the current situation and finding of more effective
anti-staphylococcals.