TITLE:
Profile of Newborns Hospitalized for Maternal Fetal Infection and Having a Positive CRP in the Pediatric Department of the Gabriel Touré CHU in Bamako, Mali
AUTHORS:
Oumar Coulibaly, Hawa Gouro Diall, Guédiouma Dembélé, Mamary Coulibaly, Fatoumata Léonie Françoise Diakité, Lala Ndrayni Sidibé, Leyla Maiga, Ibrahima Ahamadou, Abdoul Karim Doumbia, Belco Maiga, Adama Dembelé, Pierre Togo, Karamoko Sacko, Mohamed Elmouloud Cissé, Djeneba Konaté, Fousseyni Traoré, Aminata Doumbia, Yacouba Aba Coulibaly, Amadou Touré, Bourama Kané, Issa Amadou Touré, Abdoul Aziz Diakité, Traoré Fatoumata Dicko Traoré, Mariam Sylla, Boubacar Togo
KEYWORDS:
Early Bacterial Neonatal Infection, Clinical Profile, Neonatal Mortality
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.11 No.4,
December
8,
2021
ABSTRACT: Objective: Early bacterial neonatal infection (INBP) or maternofetal infection
(early neonatal sepsis) remains a concern of the pediatrician due to diagnostic
difficulties and its increased morbidity and mortality. No study has been done
in Mali on the profile of newborns admitted for INBP with positive CRP, hence
the initiation of this work with the aim of studying the epidemiological,
biological and bacteriological profile of newborns with a bacterial maternal-fetal
infection. Method: Longitudinal study descriptive (from 27 June to 3
September 2016) which concerned all newborns aged from 0 to 72 hours of life
hospitalized for confirmed early bacterial neonatal infection with a positive C-reactive protein (CRP) in
the neonatal department of the CHU Gabriel Touré. INBP was defined by the
presence of maternal and neonatal infectious risk factors, positivity of CRP
with a germ in the blood culture. Results: During the study period we
included 244 newborns for probable maternofetal infection and who benefited
from the CRP assay, 43 had a positive CRP, i.e. a frequency of 17.62%. The
sex ratio was 2.30. The majority had a low birth weight ( g) in 69.8% of cases.
Mothers were aged 18 to 35 in 93%. The majority were out of school (43.8%) and
housewives in 74.4%. The main reasons for consultations were prematurity and/or
low birth weight, respiratory distress and neonatal distress, i.e. 46.5%, 25.6% and 11.6% respectively. Among the 43 newborns with a
positive CRP, the blood culture returned positive
in 79.1% (n = 34). We deplore 2 deaths (4.7%). The main bacteria were gram-positive
cocci (Staphylococcus aureus 53.01%
and Streptococccus agalactiae 4.10%),
gram-negative bacilli (GNB) type Enterobacteriaceae
(Klebsiella pneumoniae 11.25% and E.
coli at 5.70%) and non-fermentative GNBs (Pseudomonas aeruginosa 2.80% and Acinetobacter baumannii complex 2.24%). Conclusion: Maternal-fetal infection is a hospital pathology frequently encountered in the
neonatal period. Its clinical presentation is dominated by respiratory distress,
neurological disorders and low birth weight.