TITLE:
Monophasic Synovialosarcoma of the Kidney: About a Case and Literature Review
AUTHORS:
Maryam Zaouit, Sia Nioka Pierre Xavier, Hanan Rida, Hassan Jouhadi, Tarik Chekrine, Zineb Bouchbika, Nadia Benchekroun, Nezha Tawfiq, Souha Sahraoui, Abdellatif Benider
KEYWORDS:
Kidney, Synovialosarcoma, Molecular Study, Poor Prognosis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.12 No.11,
November
30,
2021
ABSTRACT: Introduction: Primary renal synovialosarcoma (SVS) is a rare and aggressive disease in
which the metastatic potential is very high. Its diagnosis is based on
morphological and molecular studies. No therapeutic consensus has yet been
established for this histological variant of renal cancer. We describe our
experience with a patient followed at the Mohamed IV Center for cancer
treatment for primary monophasic synovialosarcoma of the kidney. Case Presentation: In October 2020, a
58-year-old patient with hypertension under treatment, consulted for right back pain without hematuria or calculus
emission. The initial examination found a slight right lumbar tenderness.
Thoraco-abdominal computed tomography revealed a cystic lesion of the superior pole of the right kidney without secondary lesions. Surgical treatment
consisted of an enlarged right total
nephrectomy using a bi-subcostal approach. The post-operative consequences were simple. Histologically, it was a poorly differentiated cystic
malignant tumor process measuring 17 cm long axis. The limits were healthy as
well as the adrenal. Immunohistology made it possible to retain a monophasic
synovialosarcoma. However, the patient did not receive genetic analysis. Given the poor prognosis of
these tumors, treatment with adjuvant chemotherapy
and radiotherapy has been imposed; as indicated in our case. Conclusion: Primary kidney SVS is a
rare, aggressive disease with a poor prognosis. However, the prognosis may be
improved by multimodal treatment. A positive diagnosis
is difficult and can be confused with other types of renal carcinoma hence the
interest in molecular biology.