TITLE:
Changes in the Physical and Mechanical Properties of Human Blood with Sustained Prophylactic Use of Acetylsalicylic Acid (Aspirin)—A Rheological Study
AUTHORS:
Trevor Corrigan, Liam O’Malley, Dorian Bailey, Hope Moseley, Jada Okaikoi, Thomas Brown, Sean Murray, William Chang, Minseo Yang, Lam Nguyen, Erin Milner, Kevin O’Donovan, Matthew Armstrong
KEYWORDS:
Hemorheology, Rouleaux
JOURNAL NAME:
Open Journal of Fluid Dynamics,
Vol.11 No.4,
November
11,
2021
ABSTRACT: While the prophylactic use of regular, low dosage, acetylsalicylic acid (aspirin) has been employed due to the inhibitory effect on platelet aggregation, few if any rheological studies validate the change in the physical and mechanical properties of human blood post-aspirin administration. The viscosity and yield stress of blood from eleven donors were assessed at varied shear rates before and after daily aspirin administration (81 mg) for 14 consecutive days. The findings indicate a statistically relevant aggregated decrease with respect to viscosity and yield stress within the study population.