TITLE:
Effect of Antimicrobial Peptides and Chemicals Produced by Animals on Liver Microsomal Enzymes CYP450
AUTHORS:
Al-Baraa Akram, Glen McCann
KEYWORDS:
Antimicrobials, CYP450, Antimicrobial Peptides
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.12 No.9,
September
28,
2021
ABSTRACT: The problem of multidrug-resistant pathogens as
bacteria, fungi and yeast in addition to the restriction of using antibiotics
as growth promoting substances in feed has attracted attention for looking for
alternative sources instead of conventional antibiotics like natural products
which have antimicrobial activity. Much interest and researches have been
focused on using natural antimicrobial peptides and chemicals extracted from
animal secretions and some insect’s venoms as they exhibit antimicrobial
activity against pathogens with lower resistance and higher synergistic effects
if they were given in combination with blends of them. In this paper, some
antibacterial peptides extracted from honeybees venom and expression with yeast Saccharomyces cerevisiae will be discussed as well as antimicrobial chemicals extracted from giraffes in
addition to their inhibitory effects on liver microsomal enzymes CYP450 will be
discussed also with its activity against microorganisms which are Agrobacterium rhizogenes, Aspergillus niger, Candida albicans and E. coli using optical density analysis technique then their minimum inhibitory
concentrations (MIC) will be determined as well as ICs 50 to measure the
potency to inhibit a biological function using programmes like Gene5, graph pad
prism and clone manager as well as testing antimicrobial activity of some
chemicals which are provided in animal secretions.