Article citationsMore>>
Masuzawa, A., Black, K.M., Pacak, C.P., Ericsson, M., Barnett, R.J., Drumm, C., Seth, P., Bloch, D.B., Sevitsky, S., Cowan, D.B. and McCully, J.D. (2013) Transplantation of Autologously Derived Mitochondrial Protects the Heart form Ischemia-Reperfusion Injury. American Journal of Physiology-Heart and Circulatory Physiology, 304, H966-H982.
https://doi.org/10.1152/ajpheart.00883.2012
has been cited by the following article:
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TITLE:
Mitochondrial Organelle Transplantation Is a Potential Therapeutic for Mitochondria Dysfunction in Severe Acute Respiratory Syndrome (SARS) Coronavirus Diseases
AUTHORS:
Catherine C. Baucom, Xian-Peng Jiang
KEYWORDS:
COVID-19, Mitochondrial Dysfunction, Mitochondrial Organelle Transplantation, Lung Repair
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.11 No.3,
September
16,
2021
ABSTRACT: COVID-19 severe symptoms and high mortality are mainly seen in elders with age-associated diseases who have mitochondrial dysfunction. Mitochondrial dysfunction is a vulnerability and comorbidity of COVID-19. Cytokine storm, and increased serum iron and ferritin and reactive oxygen species (ROS) in COVID-19 further damage mitochondria. Amelioration of mitochondrial dysfunction may be a strategy of prevention and treatment of COVID-19. We also describe mitochondrial organelle transplantation (MOT) which has restored mitochondrial function, improved the repair of injured tissues and suppressed hyperinflammation in life-threatening sepsis. MOT is a potential therapy for severe COVID-19. Finally, we report the first case of MOT for a severe COVID-19 patient. MOT is safe and might have beneficial effect on the severe COVID-19.
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