Vinodkumar, R., Vaidya, S.D., Kumar, B.V.S., Bhise, U.N., Bhirud, S.B. and Mashelkar, U.C. (2008) Synthesis, Anti-Bacterial, Anti-Asthmatic and Anti-Diabetic Activities of Novel N-Substituted 2-(4-styrylphenyl)-1H-benzimidazole and N-substituted-3[4-(1H-benzimidazole-2-yl)-phenyl]-acrylic Acid Tertbutyl Ester. Arkivoc, 2008, 37-49.
https://doi.org/10.3998/ark.5550190.0009.e05

has been cited by the following article:

• TITLE: Design, Synthesis and in Vitro Antibacterial Activity of 2-thiomethyl-benzimidazole Derivatives

  AUTHORS: Ablo Evrard, Coulibali Siomenan, Camara Tchambaga Etienne, Toure Daouda, Coulibaly Souleymane, Sissouma Drissa, Adjou Ané

  KEYWORDS: Antibacterial Activity, Benzimidazole, 2-Methylbenzimidazole Thiouronium, Halide

  JOURNAL NAME: Advances in Biological Chemistry, Vol.11 No.4, August 27, 2021

  ABSTRACT: A series of novel substituted benzimidazole (7a - n) derivatives were synthesized and characterized by 1H, 13C Nuclear Magnetic Resonance (NMR) spectra and High Resolution Mass Spectrometry (HRMS). The substitution was done in position -1 and -2 by appropriate groups. These compounds are obtained by N-alkylation reaction with thiomethyl-1H-benzimidazole intermediates (5a - g). Design of intermediates (5a - g) was made by condensation reaction between 2-methylbenzimidazole thiourunium salt (3) and functionalized halides (4) in the presence of sodium hydroxide (NaOH). Among the twenty-one compounds synthesized, ten were evaluated for their antimicrobial activity on three bacterial strains namely: Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27853. Only E. coli ATTC 25922 was susceptible to the synthesized derivatives 5g, 7f and 7h with a significant antibacterial activity (CMI is between 250 and 500 μg/mL).