TITLE:
Profile of patients with pancreatic cancer and diabetes mellitus at the University Hospital of Brazzaville
AUTHORS:
Rody Stéphane Ngam, Evariste Bouenizabila, Arnaud Mongo-Onkouo, Jile Florient Mimiesse, Ngala Akoa Itoua-Ngaporo, Motoula Latou Pérès Mardochée, Relda Itoko Okombi, Philestine Clausina Mikolele Ahoui Apendi, Deby Gassaye, Blaise Irénée Atipo Ibara, Jean-Rosaire Ibara
KEYWORDS:
Pancreatic Cancer, Diabetes Mellitus, Association
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.11 No.6,
June
30,
2021
ABSTRACT: Introduction: pancreatic cancer a poor prognosis disease for
which there is no screening. Its association with diabetes is not uncommon and
may influence the evolutionary profile. The aim of this study was to describe
the profile of diabetic patients who could benefit from pancreatic cancer
screening. Methods: we conducted a retrospective cross-sectional study
in the gastroenterology department of the University Hospital of Brazzaville,
from January 2010 to December 2019. Epidemiological variables (age, sex,
alcoholism, smoking), tumor variables (symptoms, site, size, density,
extension) and time of occurrence of both entities were analyzed using Epi info
software. Results: A total of 35 patients were hospitalized for
pancreatic cancer, of whom 17 were men and 15 women, for a sex ratio of 1.21.
The mean age of the patients was 60.3 ± 13 years. Fifteen patients (43.75%)
were diabetic, all classified as type 2. Among them, the diagnosis of diabetes
of 10 patients (66.7%) preceded pancreatic cancer diagnosis and delay between
the two pathologies was on average 3.4 years ± 5.3 months. Diabetes was
observed in 11 patients older than 60 years. The difference was significant (OR
= 4.8; 95% CI [1.1 - 22.8]; p = 0.0226). The other epidemiological variables
studied were not related to the two pathologies. Conclusion: we propose
a screening for pancreatic cancer when diabetes is discovered to patients from
60 years old, whatever their sex, especially during the first 3 years after the
discovery of diabetes.